כורכום·קורונה וירוס

כורכום וירוסים וקוביד-19

רוב האנשים שחוטפים את הוירוס המכונה קוביד-19 ברמות הקשות הם אותם אנשים עם בעיות לב, נשימה, השמנה וסוכרת…
מחקרים רבים נערכו לגבי כורכום ויכולותיו במניעה ובטיפול במחלות אלה ואם משלבים גם את היכולות האנטיויראליות שלו… הרי שאנחנו יכולים לקבל מועמד ראוי במיוחד לתמיכה וטיפול גם במקרים של קוביד-19.

במאמר מסוג סקירה שפורסם במאי 2020 בג'ורנל הרפואי Phytotherapy Research מציגים החוקרים את הפוטנציאל הטיפולי של כורכום גם אל מול קוביד-19.

Evidence suggests that curcumin has an inhibitory potential against various viral infections. The antiviral effects of curcumin were observed against viruses including vesicular stomatitis virus, parainfluenza virus type 3, vesicular stomatitis virus, flock house virus, herpes simplex virus, and respiratory syncytial virus

לכורכום יכול למנוע שכפול של וירוסים

Curcumin can potentially target critical steps of the viral replication cycle
Wen et al. have studied the effect of curcumin on viral replication, by quantification of the number of spike proteins present in cultures of Vero E6 cells infected with SARS-CoV. Their result demonstrated that the inhibitory effect of curcumin in EC50 values was higher than 10 μM on SARS-CoV replication

כורכום יכולת למנוע את החיבור של הוירוס עם הרצפטור ACE2

ACE2 is the receptor that binds with SARS-CoV-2 spike glycoprotein which facilitates membrane fusion and viral infection occurs through endocytosis. Therefore, spike glycoprotein is a potential candidate for drug targeting to inhibit the entry of virus (Utomo & Meiyanto, 2020) that in silico docking studies revealed that curcumin could potentially inhibit ACE2 to suppress COVID19 entry to the cell

לכורכום יכולת לעכב את האנזים פרוטאז שעל הוירוס

Potential inhibitory effect of curcumin on viral protease
Khaerunnisa et al. examined the role of several phytochemical compounds such as curcumin that may have the potential to inhibit the COVID-19 infection by molecular docking. Curcumin showed relatively low binding energies and inhibition constants. They suggested that curcumin could have a potential inhibitory effect on COVID-19 Mpro and could potentially act as a therapeutic agent

לכורכום השפעה על אינטרפרונים שמעודדים תגובה חיסונית טובה כנגד וירוסים

Potential effect of curcumin on interferons
There is growing evidence on the effect of curcumin on IFNs in different viral diseases
Ting Du et al. have shown that treatment with cationic carbon dots based on curcumin can suppress PEDV model of coronavirus reproduction by stimulating the production of interferon-stimulating genes (ISGs) and the cytokines ( IL8 and IL6) of Vero cells by triggering the innate immunity of the host

לכורכום יכולת טיפולית כנגד זיהומים ריאתיים, בצקות ופיברוזיס ריאתי… כמו כן הכורכום יודע גם למנוע "סערת ציטוקינים"… כל אלה הם סיבוכים המשויכים לקוביד-19.

The potential effect of curcumin in the treatment of pulmonary inflammation, edema and fibrosis
There is growing evidence on the inhibitory actions of curcumin on inflammatory cytokines. Curcumin blocks the essential signals regulating the expression of various pro-inflammatory cytokines including nuclear factor-κB and MAPK pathways
Curcumin has anti-inflammatory and anti-fibrotic effects by reducing the expression of crucial chemokines and cytokines involved in lung infection such as IFNγ, MCP-1, IL-6 and IL-10 (Sreedevi Avasarala et al., 2013). Curcumin has an inhibitory effect against the human respiratory syncytial virus (RSV) infection by preventing RSV replication, the release of TNF-alpha and downregulating phospho-NF-κB
Curcumin has been shown to inhibit the cellular inflammatory response by attenuating the cytokine/chemokine expression through the NF-кB pathway and fibrotic response during the regeneration phase of the disease via attenuating of the TGF-ß pathway
Curcumin can also inhibit apoptosis pathways mediated by the p38 MAPK pathway
curcumin has been shown to reduce collagen in experimental models of pulmonary fibrosis induced by whole-body irradiation, bleomycin and cyclophosphamide
evidence shows that prophylactic application of curcumin decreased the inflammation resulting in a reduced influx of fluid in lungs of rats under hypoxia

לכורכום יכולת לתמוך גם בנזקים הלבביים שקשורים לקוביד-19

The potential effect of curcumin in the treatment of COVID-19 associated cardiovascular damage
It has been shown that curcumin reduces inflammation and necrotic tissue in the myocardial ischemia-reperfusion model in the rat by inhibition of early growth response-1 and reduction of tumor necrosis factor-alpha and interleukin-6
Curcumin reduces myocardial ischemia-reperfusion injury through a reduction of c-Jun N-terminal
curcumin reduced the infiltration of immune cells and the expression of adhesion molecules and pro-inflammatory mediators in vascular cellskinase (JNK) and NF-κB nuclear translocation

הכורכום יכול לתרום במניעת פגיעה כלייתית

The effect of curcumin in COVID-19 associated kidney damage
Xu et al. have shown that curcumin could potentially upregulate the ACE2 and ACE2 mRNA resulting in improved renal blood flow and have a potential anti-fibrotic effect in kidneys in type 2 diabetic rat models
Curcumin potentially reduces renal fibrosis at priming and activation stages by suppressing the inflammation caused by reduced MCP-1, NF-𝜅B, TNF-𝛼, IL-1𝛽, COX-2, and cav-1 levels.
Curcumin also increases the expression of anti-inflammatory factors such as neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4), mannose-6-phosphate receptor binding protein 1(M6PRBP1) and heme oxygenase-1 (HO-1).
Curcumin also targets MAPK/ERK, TGF-𝛽/smads and PPAR-𝛾 pathways in animal models of kidney disease

לכורכום יכולת למנוע נזקים של עקה חימצונית מוירוסים

The potential effect of curcumin in inhibition of oxidative stress in viral infection
Curcumin has the electron transfer capability to scavenge various intracellular small oxidative molecules
Curcumin can up-regulate the expression of glutathione (GSH), and inhibits the generation of reactive oxygen species (ROS) and malondialdehyde
Curcumin can reduce the infection with influenza A virus and influenza pneumonia by activating Nrf2 signaling and inducing the generation of various antioxidants.
Curcumin also suppresses influenza A virus -mediated oxidative stress and indirectly inhibits influenza A virus -induced activation of TLR2/4, MAPK and NF-κB pathways. The above processes may suppress
the influenza A virus -mediated inflammation and replication. Therefore, curcumin potentially have beneficial antioxidant properties in the treatment of SARS-COV-2 mediated oxidative stress in the lungs

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